Search results for "Chronic inflammatory disease"
showing 8 items of 8 documents
Surgical Emergencies in Crohn’s Disease
2015
Crohn’s disease, as a chronic inflammatory disease of unknown etiology that can affect any part of the alimentary canal from the mouth to the anus, has a highly variable course and a very unpredictable evolution. Even surgery does not cure CD, it has however a relevant role in its treatment in combination to medical therapy during the large course of the disease; indeed almost each patient is submitted to a surgical intervention during his life. Nowadays, surgery is considered the last treatment to use whenever medical therapy is insufficient to control symptoms; this choice involves an intervention on more serious patients with more surgical complications. Surgery finds in the Crohn’s dise…
Characterization of endometriosis-associated immune cell infiltrates (EMaICI)
2016
Objective: To identify and characterize endometriosis-associated immune cell infiltrates (EMaICI). Furthermore, to define occurrence and size of EMaICI in various types of endometriosis. Methods: Immune cells were characterized in samples of 60 premenopausal women with histological proven endometriosis. Therefore, immunohistochemical staining with monoclonal antibodies for CD3, CD4, CD8, CD45RO, CD25, CD56, CD68, and CD20 on sections of paraffin-embedded endometriotic tissue was performed. Results: EMaICI were observed in all the types of endometriosis, and characterized as T lymphocytes (CD3+), helper T lymphocytes (CD4+), cytotoxic T lymphocytes (CD8+), antigen-experienced T lymphocytes”m…
Expression, Localization, and Significance of Vascular Permeability/Vascular Endothelial Growth Factor in Nasal Polyps
2005
Background The exact etiologic mechanisms leading to the formation of nasal polyps have remained largely obscure. A key phenomenon of this specific type of chronic inflammatory disease in nasal respiratory mucosa is remarkable edema. Vascular permeability/vascular endothelial growth factor (VPF/VEGF) plays an important role in inducing angiogenesis and modulating capillary permeability. Objective To study the expression and localization of VPF/VEGF as a putative key factor in nasal polyp development. Methods Specimens of nasal polyps (n = 12) were harvested during endonasal sinus surgery in patients with polypous chronic rhinosinusitis. Specimens of healthy nasal respiratory mucosa (n = 12)…
Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity.
2022
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.
A new exciting hypothesis: direct correlation between periodontitis and clinical evolution of COVID-19 patients.
2020
The aim of the present opinion article is to hypothesize a possible correlation between clinical evolution of COVID-19 and a chronic inflammatory disease such as periodontitis. Reviews have been performed about the correlations between COVID-19 and IL-6, COVID-19 and diabetes, diabetes and periodontitis. Several studies discussed the role played by IL-6 in the pathogenetic mechanisms of COVID-19. A recent study found that COVID-19 adult patients with diabetes, without other comorbidities, were at greater risk of numerous diseases COVID related, such as severe pneumonia and excessive uncontrolled inflammatory responses. Besides, serum levels of inflammation-related biomarkers, such as IL-6, …
Combined treatment of hidradenitis suppurativa with intense pulsed light (IPL) and radiofrequency (RF)
2019
BACKGROUND Hidradenitis suppurativa is a chronic inflammatory disease with high burden. Treatment options are often unsatisfactory. We assessed the effect of a combination therapy of intense pulsed light (IPL) and radiofrequency (RF). METHODS The explorative study included 47 patients and was performed as a prospective, monocentric, randomized, three-arm parallel-group design trial with a prior 12 weeks observation period. Treatment arms were IPL and RF monotherapies or IPL + RF combination therapy. After 12 weeks, all patients received IPL + RF for additional 12 weeks (cross-over). Primary endpoint was the change in active lesion numbers, secondary endpoint the change in Dermatology Qualit…
The association of periodontal diseases with metabolic syndrome and obesity
2020
Periodontitis is a multifactorial chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth-supporting apparatus. Globally, it is estimated that 740 million people are affected by its severe form. Periodontitis has been suggested to be linked to obesity and metabolic syndrome. Obesity, defined as excessive fat accumulation, is a complex multifactorial chronic inflammatory disease, with a high and increasing prevalence. Metabolic syndrome is defined as a cluster of obesity, dyslipidemia, hypertension, and dysglycemia. Obesity, metabolic syndrome and periodontitis are among the most common non-communicable diseases and a l…
Eicosanoids, Inflammation and Chronic Inflammatory Diseases: Pathophysiology, Health Effects and Targets for Therapies FIRST EDITION
2015
Eicosanoids constitute a large and expanding family of bioactive lipids synthesized from polyunsaturated fatty acids (PUFA) to either pro-inflammatory omega-6 arachidonic acid (AA) or anti-inflammatory omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In these last cases, two essential fatty acids (FAs) (ω-6 linoleic acid (C18:2n6) and ω-3 linolenic acid (LA) (C18:3n3) are utilized as substrates and a series of desaturase and elongase enzymes are essential for their production. Among these different members, the AA-derived eicosanoids operate as potent signaling mediators that provide an efficient way for cells to respond to various stimuli. As a result, they act as part o…